Enzyme Research Laboratories in Italy
CABRU distributes Enzyme Research Laboratories in Italy, a United States manufacturer in South Bend, Indiana, specialising in the purification of coagulation proteins, enzymes and inhibitors. The CABRU catalogue lists 110 references, 45 of them relating to individual factors of the coagulation cascade.
About Enzyme Research Laboratories
Enzyme Research Laboratories is based in South Bend, Indiana (United States), with an office in Swansea in the United Kingdom, and states over forty years of activity manufacturing enzymes and cofactors for basic coagulation research. It is a vertical manufacturer in a single field: not a generalist catalogue with a haemostasis section, but a catalogue built entirely around the coagulation cascade and its individual components.
What Enzyme Research Laboratories makes
- Zymogens and activated enzymes purified from human and bovine plasma, including forms with the Gla domain removed (des-gla) and inactivated proteins. → Proteins
- Active-site blocked enzymes, used as controls and as mechanistic tools in cascade studies.
- Monoclonal and polyclonal antibodies against coagulation factors, including matched pairs, and ELISA reagents for their detection. → Antibodies
- Chromogenic substrates and snake venom proteins, including the factor X activator. → Biochemicals
Beyond human and bovine
The ERL catalogue also covers coagulation proteins of canine, murine, porcine, rabbit and rat origin. That is uncommon coverage, and for a laboratory working on animal models it is the difference between rebuilding an assay with heterologous reagents and using the protein of the correct species. In the CABRU catalogue 14 references are of bovine origin; other species are checked case by case with the manufacturer.
Application areas
Haemostasis, thrombosis and fibrinolysis research, mechanistic study of individual factors and their inhibitors, and the development and characterisation of enzymatic assays. The manufacturer states that human source material is tested and found negative for the communicable diseases checked, and lists the products as intended for research use. → Haemostasis and coagulation
How CABRU frames the enquiry
With these reagents the right question is not which product, but which form: zymogen or activated enzyme, with or without the Gla domain, free or blocked active site, and in which species. CABRU collects those four pieces of information before quoting, because they are what separates references with nearly identical names. The intended use of each reference is verified case by case. CABRU distributes Enzyme Research Laboratories in Italy on a non-exclusive basis. → Request information and a quote